4-Fluoro-2-methyl-1-cyanobenzene
4-Fluoro-2-methylbenzonitrile (CAS 147754-12-9) is a fluorinated aromatic nitrile used as a key building block in pharmaceutical R&D. The nitrile group can be converted to amidines, carboxylic acids, amides, or tetrazoles, while the C-F bond enables downstream cross-coupling chemistry.
Fluorinated benzonitriles of this type are frequently used in the synthesis routes of modern active pharmaceutical ingredients, where the fluorine atom improves metabolic stability and binding affinity of the final molecule.
4-Fluoro-2-methylbenzonitrile (CAS 147754-12-9, C8H6FN) is a difunctional aromatic building block that pairs a nitrile group with an activated aryl fluoride. The nitrile is a synthetic hub: it can be hydrolysed to the carboxylic acid or amide, reduced to the benzylamine, or converted to amidines and tetrazoles without disturbing the rest of the ring.
The fluorine substituent is not merely a spectator. Aryl fluorides of this type are widely used to fine-tune the metabolic stability, lipophilicity and binding affinity of a final active molecule, and the C–F bond itself is a useful handle for nucleophilic aromatic substitution and metal-catalysed coupling. The 2-methyl group adds steric definition and directs further substitution on the ring.
The compound is used mainly as an advanced intermediate in pharmaceutical R&D, where the nitrile and fluoride are elaborated in sequence to reach fluorinated heterocycles and substituted benzamides. Its combination of a small, well-defined ring with two orthogonal functional groups makes it efficient to work with on both milligram screening scale and pilot scale.
Medicinal chemists frequently introduce fluorine late in a lead-optimisation campaign to block metabolic soft spots and adjust pKa without adding bulk. A ready supply of a defined, high-purity fluorinated benzonitrile keeps that work on schedule instead of waiting on a bespoke synthesis.
The same reactivity makes the scaffold useful in crop-protection and specialty fine-chemical synthesis, where fluorinated aromatic nitriles are common precursors to anilides, amidines and heteroaromatic ring systems.
Because R&D programmes rarely stop at one compound, we also support custom synthesis and scale-up of related fluorinated aromatics. Our process team takes a route from gram-scale feasibility through kilogram and pilot quantities, optimising yield, impurity profile and crystallisation before it is transferred to commercial production.
Typical requests include ring-substituted fluorobenzonitriles, fluorinated benzylamines and the corresponding benzoic acids and amides, along with custom specifications on assay, residual solvent and particle size. If you need a compound that is not listed on this site, send us the structure and target quantity and we will come back with a feasibility assessment and indicative timeline.
4-Fluoro-2-methylbenzonitrile is supplied in 200 kg net iron drums, with smaller pack sizes available for process-development quantities. It is a liquid at room temperature, so it can be charged by pump or by weight.
Store in tightly closed containers in a cool, dry, well-ventilated place, away from heat, sparks and open flames, and separate from strong oxidising agents. Keep containers closed when not in use and ground equipment during transfer. Standard lead time is approximately four weeks, confirmed by email at the time of order.
The material is supplied at ≥ 98.0 % (GC) with a controlled appearance and a full COA per batch. A TDS and a GHS-compliant English SDS are available on request. Minimum order quantity is 1 kg for evaluation; kilogram to multi-kilogram quantities are available for process development, with larger campaigns produced at our Lanzhou base against an agreed specification.
If you are onboarding a new intermediate supplier, our checklist qualifying a new chemical supplier covers the documents and audits worth requesting before you commit to a route.
Tell us your required quantity and destination. Our sales team replies within 24 hours with pricing, lead time, and shipping options. COA and SDS available on request.
4-Fluoro-2-methylbenzonitrile, also known as 4-Fluoro-2-methyl-1-cyanobenzene, is a pharmaceutical intermediate (colorless liquid, purity ≥ 98.0%). It is supplied by Qingdao Marram Chemical Co., Ltd. for pharmaceutical, agrochemical, and fine chemical applications.
Our 4-Fluoro-2-methylbenzonitrile is available at ≥ 98.0% purity (COA provided with every batch), appearance: colorless liquid. Molecular formula: C8H6FN, molecular weight: 135.14 g/mol. Custom specifications can be discussed for bulk orders.
Yes, a GHS-compliant English Safety Data Sheet in the standard 16-section format is available instantly via the document request form on this page.
The minimum order quantity is 1 kg. Final MOQ and volume pricing are confirmed by email. 4-Fluoro-2-methylbenzonitrile is produced and shipped with a typical lead time of approximately 4 weeks after order confirmation. Please confirm current availability and lead time by email before ordering. Larger quantities from kilograms to metric tons can be produced at our Lanzhou manufacturing base.
Email chaijing@marramchem.cn or call +86-15930139955 with your required quantity and destination. We respond within 24 hours with pricing, lead time, and shipping options (air, sea, or courier).
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